a tool for identifying drug-targetable redox-active disulphides

Ig kappa chain V-II region 26-10

Intramolecular

Cysteine 23 and cysteine 93

A redox-regulated disulphide may form within Ig kappa chain V-II region 26-10 between cysteines 23 and 93.

Details

Redox score ?

80

PDB code

Structure name

crystal structure of the single-chain fv fragment 1696 in complex with the epitope peptide corresponding to n- terminus of hiv-2 protease

Structure deposition date

2004-03-30

Thiol separation (Å)

2

Half-sphere exposure sum ?

87

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

23

Residue number B

93

Peptide name

Ig kappa chain V-II region 26-10

Ligandability

Cysteine 23 of Ig kappa chain V-II region 26-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Ig kappa chain V-II region 26-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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